Network Architecture, Receptive Fields and Neuromodulation in Primary Auditory Cortex: a computational study

Two fundamental issues in auditory cortical processing are the relative importance of thalamocortical vs. intracortical circuits in shaping response properties in primary auditory cortex (ACx), and how the effects of neuromodulators on these circuits affect dynamic changes in network and receptive field properties that enhance signal processing and adaptive behavior. To investigate these issues, we develop a computational model of layers III and IV (LIII/IV) of AI, constrained by anatomical and physiological data. In this talk, we will discuss how the local and global cortical architecture shape receptive fields (RF) of cortical cells, as well as how different well-established cholinergic effects on the cortical network reshape frequency tuning properties of cells in ACx.
Contacto: ebiomat@famaf.unc.edu.ar